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Insulin Resistance

Insulin resistance: causes, symptoms, and treatment:
Insulin Resistance
What are the causes of insulin resistance?

Probably a factor as to why they're doing so poorly. Although we've been able to identify specific things that put you at risk, the actual mechanism by which insulin resistance manifests itself remains elusive. Notably, the most notable contributors are:
Excess weight, especially in the lower abdomen: Excess fat in the abdomen (this is called central obesity) and around the limbs (known as visceral fat) is a risk factor for insulin resistance. Even if your body mass index (BMI), which is in proportion to your weight and your height, is in the normal range, men are more likely to have a waist size of> 40 inches and women with a waist size of> 35 inches are more likely to have insulin resistance.

Asians are more likely to develop T2DM, so risky waist-sized cuts are even lower:> 35.5 inches in men and 31.5 inches in women (ADPI). Researchers believe that these fat cells release inflammatory markers known as adipocytokines or adipokines, which may play a role in the development of insulin resistance.

Miraculous lifestyle: Not getting enough physical activity every day is associated with insulin resistance.

There are also causes related to obesity insulin resistance (Optodate, 2018). These include:

Some medications: Med medications involved in insulin resistance include steroids (e.g., prednisone), some antipsychotics, some HIV medications, and oral contraceptives.

Some treatment conditions: Treatment conditions that affect hormones can cause insulin resistance, including Cushing's syndrome (high levels of cortisol) and acromegaly (high levels of growth hormone).

Pregnancy: Hormones associated with pregnancy, including placental lactogen, may play a role in the development of insulin resistance. It can lead to gestational diabetes in sensitive women.

Other fatty problems: Abnormal distribution conditions of fat (lipodystrophy) or fat loss (lipoatrophy) can cause severe insulin resistance.

Type the type of insulin resistance: This is due to a genetic condition that causes problems with the insulin-signaling pathway.

Type B insulin resistance: This is due to antibodies that block insulin receptors.

Other inherited diseases: Leprechachoism and Robson-Mendenhall syndrome are rare cases where insulin receptors are mutated and cause insulin resistance.

What are the signs and symptoms of insulin resistance?
Some people have no symptoms of insulin resistance. Others will only realize that they are insulin resistant only if they are diagnosed with prelibitis or T2DM. Symptoms may include diabetes and uncontrolled blood sugar control:

Increased thirst (polydipsia)

Frequent urination (polyuria)

Extreme hunger (polyphagia)

Lack of energy

Weight loss

Vision changes

Breastfeeding, tingling, or pain

Illness cured

Recurrent infections

Some have insulin resistance that may have additional symptoms that are not directly related to T2DM. These include:

Armpit and neck arching (Acanthosis nigricans)

Leather tag

Baldness (alopecia)

Presence of menopause (amenorrhea) or infertility in women

Excessive hair growth in women

Problems with Fat Tissue (Loss or Overgrowth), Muscle Tissue (Cramp or Overgrowth), or Growth (Obstructive or Growth) (Optodate, 2018)

How is insulin resistance diagnosed?
Healthcare providers do not routinely test for insulin resistance. More commonly, insulin resistance is found in blood tests for diabetes. Diabetes screening tests include the FPG test, OGTT, and hemoglobin A1C (HBA1C) test.

Suggests that fasting insulin levels and fasting triglyceride levels may be effective in detecting insulin resistance (fasting means not eating or drinking anything for at least eight hours).

However, when diagnosing insulin resistance, healthcare providers usually consider how patients are treated and their other health conditions usually occur alongside insulin resistance (e.g., high blood pressure and abnormal cholesterol levels). More specific tests can be performed on those who seem to have inherited insulin resistance

How is insulin resistance managed?
Insulin resistance can lead to a number of problems, including cardiovascular disease and T2DM, and it is important to take action. Insulin resistance is primarily managed by lifestyle changes.

The two most important things a person can do in contrast to insulin resistance include losing weight and becoming more active. According to the American Diabetes Association, only 7% weight loss can help insulin resistance (ADA, 2009). Additionally, everyone is recommended to do moderate exercise at least five times a week.

If you have already identified T2DM, you may need to take several medications to make you more sensitive to insulin. One of the most commonly prescribed drugs is metformin (brand name Glucophage). Metformin may also be prescribed to prevent progression to T2DM for people with prophylaxis. However, it is an off-label use (meaning it is not an FDA-approved use of the drug).

If you develop insulin resistance due to one of the rare, genetic factors, managing your condition may be more involved and you should consult your healthcare provider.

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